liquid handling
Multichannel technique on a 96-well plate
Compare single-channel and multichannel work on a 96-well plate, including tip seating, depth, angle, and the bias a loose tip leaves.
8 October 2026 · 7 min read
Topic cluster
Liquid handling
Pipetting technique, tip choice, calibration checks and where manual and automated handling each fail.
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biosafetyspecificationenquiryglossarytroubleshootingpipettingcalibrationpipettesplatestechniquemetrologysolventsconsumablesliquid handlingautomationbalancesfilter tipsplate maps
26 articles
liquid handling
Plate maps so a robot and a person agree
Compare a human plate map with a robot deck map so well identity, A1 orientation, replicates, and controls stay the same.
8 October 2026 · 7 min read
liquid handling
Pre-wetting tips and volatile solvents
See why pre-wetting saturates the air cushion, why ethanol-class solvents still drip, and when positive displacement is the better class.
8 October 2026 · 7 min read
liquid handling
Questions before a pipette enquiry
List volume range, displacement type, channels, tip family, calibration documents, and chemical exposures before you send a pipette enquiry.
8 October 2026 · 7 min read
liquid handling
Serological pipettes are a different tool
Tell a blow-out serological pipette from a micropipette, use a controller, and retire a cracked pipette before it delivers a wrong millilitre.
8 October 2026 · 7 min read
liquid handling
Service intervals are not a guess from the internet
Set a pipette service interval from usage, liquids, and the manufacturer recommendation, and check a dropped pipette before it returns.
8 October 2026 · 6 min read
liquid handling
Small volumes near the bottom of the range
Diagnose noisy results at the bottom of a pipette range, move to a lower-range instrument, and watch pre-wetting and the first stop.
8 October 2026 · 7 min read
liquid handling
Temperature of the liquid changes the volume
Equilibrate cold liquids and warm pipettes before you trust an air-displacement volume, and separate that error from a weighing drift.
8 October 2026 · 8 min read
liquid handling
Tip fit is part of the measurement
Write a tip specification that names the cone, the family the pipette was tested with, and what a universal claim does not prove.
8 October 2026 · 7 min read
liquid handling
Training a new student without blaming the kit
Define the stops, tip seating, angle, pre-wet, and balance check a new student must show before a reagent kit is blamed.
8 October 2026 · 7 min read
liquid handling
Troubleshooting a dripping pipette
Name the seal, shaft, solvent, and piston causes of a dripping pipette, and keep that pipette out of service until it is checked.
8 October 2026 · 6 min read
liquid handling
Troubleshooting scattered replicates
Name the technique, tip, temperature, mixing, and evaporation causes of scattered replicates, and what a method specification should record.
8 October 2026 · 7 min read